Evolution of p53 Transactivation Specificity through the Lens of a Yeast-Based Functional Assay
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چکیده
منابع مشابه
Evolution of p53 Transactivation Specificity through the Lens of a Yeast-Based Functional Assay
Co-evolution of transcription factors (TFs) with their respective cis-regulatory network enhances functional diversity in the course of evolution. We present a new approach to investigate transactivation capacity of sequence-specific TFs in evolutionary studies. Saccharomyces cerevisiae was used as an in vivo test tube and p53 proteins derived from human and five commonly used animal models wer...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2015
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0116177